naomi֥γ͡ФѸʱnaomiǤ 



ʰդλΥ꡼˥ڤӰ̤λΥ꡼˥󥰤ΤߤΤդ򾵤äƤޤܤϤǤ䤤碌˾αΤϤäˤƤλݤ⤪

ʿǯĴˤܤˤǤμΨ20Ǥ¤θ򤷤ƤϤ鷺14.4Ǥ屡ǡʥᥤƥʥ󥹡ˤǤڤ¤ΥåɬܤǤ



ϻ¤Ǣ¤ˤĤƽ񤤤ƤߤȻפޤ

ͤϻ¤λɤΤ餤¸ΤǤ礦

ǶǤϡֻ¤Ϻٶݤˤ봶ɤפȸΤλ¤Ȥʤޤ餪褽50ǯϻ¤θϤޤǤ

1965ǯDr.Loeϥץ顼ˤ¸Ū˻򵯤ޤץ顼뤳Ȥˤɤʤʤ뤳Ȥ򼨤ޤץ顼¤ľܤθǤ뤳ȤΤǤðŪץ顼ȸޤ

ϤޤɤκٶݤˤΤϤ狼äƤޤǤ

1988ǯDr.Socranskyϻﲼץ顼Microbial complexȤǰȯɽޤred complexȤPorphyromonas gingivalis,Tannerella forsythia,Treponema denticola, ΩϤȤAggregatibacter actinomycetemcomitansǤȿ˲˴Ϳ¸ٶݤȤƼޤðŪץ顼ȸƤӤޤ

κ¤θݤꤵϤޤ ߤǤϻ¤ʣκٶݤˤ봶ɤǤ狼äƤޤ

ޤ˺ǶǤϰҥ٥ǤθԤƤޤ
Ƕᶽ̣ȥԥåȤƤPorphyromonas gingivalisgingipainsǤ϶̣Ǥ

¤Ͽʹ֡ʽɼˤȱɸ浡ǽȺٶݡʴΡˤߺѤˤäȯɤޤ

periodontal disease
 
ºٶݤǡLPSˤȿ˲Ǥ˥ޥեϤȤΤɸ˦ȿƥȥIL-1 IL-6 TNF-ˤʪPGE2ˤޤη̡˲줿ȿ˲ޤ

Υơޤϻ¤Ǣ¤ǤɤΤ褦˻¤Ǣ¤ϢƤΤ򸫤Ƥޤ

diabetes

ޤθäƱ⤬¡Ǣ¤ȿǤ֤³AGEsޤޥե˦ˤAGEsΡRAGEˤ뤿ɺ˦ľܺѤΤ𤷤ƥȥξ徺˱ƶޤ

ޤ¤αȿǻ줿TNF-Ϸͤ򲼤륤󥹥Ư˸ޤ

ƺǽäᤷޤ1965ǯDr.LoeääƤޤ
ץ顼ȥ뤳ŤǤϺǤפʽˡǤꡢץ顼ȥʤƼŤϤꤨʤ 

brushing

ʿǯλʼĴΥǡǤܿͤλ᤭βǤʿǯΥǡǤߤȡ%οͤ󡢤ʤϣᤤƤˤʤޤ

ʤ˻᤭ƤΤ...ɤܿͤλ¤ͭΨϲʤΤǤ礦
¤ˤץ顼ȥϼʬǤϸ³ȤǤϤʤǤ礦΢֤ڤʤΤŪȤΥץ顼ȥǤϡ

ãοŤҸƤƤ⣱%᤭ǤƤͤϤۤȤɤޤ
ʾǤץ顼ĤäƤл꤬ޤɤƤݥå̤ϤƤꡢٶݤ䤹֤Ǥ

ȤǤϤʤǤ礦
˴ͤȻãʱΤϤƴͤΥץ顼ȥ򤷤ƤͻӤǤ

꥿˥եλΥ꡼˥󥰤ǤѸѤݥåΥץ顼 ʬʾ夫ƳǧޤϿΤ餺ƣܤޤñ˷׻УĤλˣʬʾλ֤򤫤ץ顼ˤʤä֤ǽΥåǤޤ1mm­餺򸫤Ĥ뤿ˤϻ̤ˤʤиޤ

ݥåȤбΤ褦ͯƤޤޤ¤ݥåȤϽз⤢ޤбդΤɸ椹뤿ʪǤ餬ãλФγǧ˸ޤμ¤ʥݥåγǧΤ屡ǤʱΤ˥ȤɬĤޤñդդμ¤˽ѼԤμ¤˴ͤλǧ뤿Ǥ

ޤŰŪ˹ԤʱΤΥ꡼˥󥰥롼ϴļȤʤäƤޤ

Ǣ¤μŤ֤硢ˤϣǤ츮Ȥ㤨ޤ

Ƥط櫓ǤϤޤ󤬡¤򥳥ȥ뤹ˤäǢ¤ξ֤ˤƶͿǤκ︺ǤСϴͤǤϤʤפȤʤΤǤϤʤǤ礦

̤ФƤʱΡ

ĥޤ


ޥϥ˥ȤΥ֥
ʻʱKimΥ֥
ʥYUΥ֥
ʻʱnaomiٶ֥



ޥ׸ʰDr.IritaniΥ֥
ʥsachiΥ֥ 
ʥAkiΥ֥